Peptic ulceration in men. Epidemiology and medical care.

Cigarette smoking, chronic peptic ulceration, and pepsin 1 secretion.

The relationship between the secretion of pepsin 1 (the most electronegative of the pepsins), and the smoking habits of 219 patients has been investigated. Significantly more cigarette smokers with peptic ulceration (72.5%) secreted pepsin 1 in greater than trace amounts after pentagastrin or histamine than did non-smokers with ulceration (51.2%). Differences of a similar order were found for m...

Fall in peptic ulcer mortality associated with increased consultant input, prompt surgery and use of high dependency care identified through peer-review audit

OBJECTIVES Patients with peptic ulceration continue to present to surgeons with complications of bleeding or perforation and to die under surgical care. This study sought to examine whether improved consultant input, timely interventions and perioperative care could reduce mortality from peptic ulcer. DESIGN Prospective collection of peer-review mortality data using Scottish Audit of Surgical...

Free radicals and the pathogenesis of disease.

In this issue of the Medical Journal of Malaysia, A. S. Salim reports on his experience with free radical scavengers in the treatment of refractory peptic ulceration!. Although the number of patients in his study was small and the trial was open and non-comparative, the results obtained are interesting enough to justifY further research into the role of free radicals in the pathogenesis of pept...

The surgery of peptic ulceration.

Post-bulbar and coexisting ulceration: unique features of peptic ulcer in Hyderabad.

Post-bulbar ulceration is uncommon, but a pilot study in Hyderabad showed a high incidence. We therefore carried out a prospective endoscopic study of the distribution of peptic ulceration and its relation to symptoms and demography. Of the 360 consecutive patients referred for endoscopy, 113 (92 men, 21 women) had peptic ulceration. Median age 35 years, median duration one year. Five patients ...